Price Discovery – Piazza Carlo Giuliani http://piazzacarlogiuliani.org/ Fri, 03 Dec 2021 21:39:43 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://piazzacarlogiuliani.org/wp-content/uploads/2021/03/cropped-icon-1-32x32.png Price Discovery – Piazza Carlo Giuliani http://piazzacarlogiuliani.org/ 32 32 Kangaroo Court: Building a competitive AI strategy | Association of Certified Electronic Discovery Specialists (ACEDS) https://piazzacarlogiuliani.org/kangaroo-court-building-a-competitive-ai-strategy-association-of-certified-electronic-discovery-specialists-aceds/ Fri, 03 Dec 2021 21:39:43 +0000 https://piazzacarlogiuliani.org/kangaroo-court-building-a-competitive-ai-strategy-association-of-certified-electronic-discovery-specialists-aceds/

The essence of formulating a competitive strategy is to relate a business to its environment. Today, few conversations about industry environment and market forces can go very far without discussing data, its challenges, and the opportunities it presents. Almost every legal department and law firm has invested time and resources in developing strategies to harness the value of data through cross-functional teams and advanced exploration tools. For a business to achieve its goals, it must develop the appropriate policies for the implementation of artificial intelligence (AI) and automation across the enterprise.

While it sounds simple, it is not such a simple task given the forces at play. After all, competition in an industry is rooted in its underlying economic structure and goes far beyond the behavior of current competitors. . The state of competition in an industry depends on five fundamental competitive forces: the threat of new entrants; bargaining power of suppliers; the bargaining power of buyers; rivalry between existing businesses; and the threat of substitute products or services. In the AI ​​world, there is a clear advantage to those who are starting the process of introducing AI solutions to better understand their data. The more AI initiatives are left on the ‘road map’ or unfinished, the more threatened a business is from the forces listed above.

The acceleration of our innovation in recent times is a reaction to forces that have been underway for centuries, leading boards to a point where new strategies are needed to meet the challenge. The fourth industrial revolution (IR) is well underway, heralding a series of social, political, cultural and economic upheavals that will take place during the 21st century. The first IR (1760-1840) gave birth to the mechanization of industry through the use of steam and hydraulic energy. The impact was primarily felt by the farming community, transforming an agrarian society into an industrial society based on consumption. Many people could no longer cultivate as their land was occupied by factories, necessitating massive retraining into trades such as boilermakers, ironworkers, mechanics, and other roles that supported machines that needed to be made or repaired.

The second IR (1870-1914) saw the expansion of electricity, oil and steel. It was a phase of rapid standardization and industrialization, leading to the introduction of public transport and airplanes. Introducing these two things would transform the world forever. Steel would replace iron in the construction industry as a sturdy, cheaper alternative to building railroads, ships, skyscrapers, and larger bridges. Michael Faraday began to play with the idea of ​​electricity. Then, a few years later, Thomas Edison and Sir Joseph Swan perfected their design of a practical light bulb for home use.

The third IR (1970-2000) can be summed up by globalization and the birth of the Internet. Hailing from the United States, Japan and Europe, the third IR gave birth to new ways of communicating across and within national borders. This would radically change the nature of supply chains, social interactions, the financial services industry, connectivity, defense technologies and finally give birth to e-commerce. The third IR made the world a smaller place and would lay the foundation for the fourth IR through the standardized use and access to information technology and the explosive growth of data that resulted from it.

We are now in a period of opportunity, but it is clear that fortune favors the daring. The argument that it’s worth the wait and see how early adopters test the application of AI solutions across different functions is valid, but not everyone is a big ship that needs leeway. important to adjust heading. Waiting too long presents its share of problems, it is only in the age of AI that these concerns can be magnified given the accelerated returns once a company has done the hard work and created libraries of AI models. Early adopters with consistent competitive strategies will differentiate themselves by instantly delivering valuable information that previously required teams of specialized knowledge workers. Would you hire a company that has built its human capital around sophisticated technology, or a company that leverages AI tools in addition to the human knowledge worker? One option allows a company’s talent, the other gives AI a supporting role.

To guard against this outcome, a company can begin the process of defining its AI strategy in a consistent and meaningful way. For example, to deal with the five competitive forces, there are three generic strategic approaches that are potentially effective in outperforming other companies in a sector:

  • Global cost leadership
  • Differentiation
  • To concentrate

Overall cost control is achieved through a set of functional policies aimed at this fundamental objective. This requires the aggressive construction of large-scale facilities; vigorous search for cost reductions based on experience; strict control of costs and overheads; avoidance of accounts receivable on margin; minimization of costs in areas such as R&D, service, sales force, advertising, etc. A low-cost position defends the business against strong buyers, as buyers can only exercise their power to lower prices to the next most efficient competitor. Achieving a low overall cost position often requires a high relative market share or other benefits, such as favorable access to raw materials. This may well require designing products to facilitate manufacturing, maintaining a wide range of related products to spread cost and service to all major customer groups to create volume.

Differentiation is achieved by creating something industry-wide that is considered unique. Differentiation approaches can take many forms, including design or branding, technology, special features, customer service, dealer network, or other dimensions. Differentiation, if achieved, is a viable strategy for achieving above-average returns in an industry, as it creates a defensible position with the five competitive forces, albeit in a different way than leadership in costs. Differentiation provides isolation from competitive rivalry due to customers’ brand loyalty and resulting lower price sensitivity. Differentiation can sometimes prevent gaining high market share. It often requires a perception of exclusivity, incompatible with a high market share.

The focus is to focus on a group of buyers, a segment of the product line or a particular geographic market. The whole focus strategy is built around serving a particular target very well, and each functional policy is built with this in mind. The strategy is based on the premise that the company can serve its narrow strategic target more effectively or efficiently than competitors who compete more widely. As a result, the company manages either to differentiate itself by better meeting the needs of the target, or to reduce its costs to serve this target, or both. Even if the concentration strategy does not achieve low cost or market differentiation, it does achieve one or both positions vis-à-vis its narrow target market.

Whichever route the management team decides to take, the growing influence of the Fourth IR has made the development of these strategies a time sensitive issue. Basically, we are talking about harnessing useful information in order to make good decisions. Mankind has operated on these terms ever since we understood the need to build a fire for food, warmth, and protection. The difference with the fourth IR over its predecessors is the speed of innovation itself. The very nature of our organization as a society is changing under our feet as we venture into a new world of surveillance, virtual reality, and questions regarding the state’s responsibility to provide a universal basic income to sections of the world. most at-risk workforce. for automation. Competing in this world requires dedication and resources deployed across the company. Without a commitment to invest in their future, businesses risk being left in the past.

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Discovery is pushing for remaining 500 unvaxxed staff to ‘cross the finish line’ https://piazzacarlogiuliani.org/discovery-is-pushing-for-remaining-500-unvaxxed-staff-to-cross-the-finish-line/ Wed, 01 Dec 2021 16:20:00 +0000 https://piazzacarlogiuliani.org/discovery-is-pushing-for-remaining-500-unvaxxed-staff-to-cross-the-finish-line/

Afternoon Drive host John Maytham chats with Dr Ron Whelan, leader of Discovery’s Covid-19 task force.

  • Only 1 Month Left Before Discovery Enters Mandatory Vaccination Policy
  • Discovery was one of the first large South African companies to announce a mandatory jab order in September
  • Since then, the staff vaccination rate has increased from 22% to 94%
  • Time is running out for more than 500 employees who have yet to receive the jab

Discovery Group offices in Sandton. Image: Abigail Javier / EWN

Discovery says he still has hopes that other unvaccinated workers at the company could get bitten by Jan. 1, 2022.

In September, Discovery announced that it would be implementing a mandatory Covid-19 vaccination policy for employees in South Africa in the New Year.

At the time, only 22% of its workforce had been vaccinated. Three months later, the staff vaccination rate jumped to 94%.

Dr Ron Whelan, leader of Discovery’s Covid-19 task force, said about 500 out of 10,500 employees remain unvaccinated.

Some have promised to get stung, but many refuse to do so.

RELATED: 94% of Discovery Staff So Far Vaccinated Thanks to Mandatory Policy – Adrian Gore

Dr Whelan, who is also commercial director of Discovery Health, said the company has not abandoned the remaining group of unvaccinated workers.

“We’re going to do everything we can to get everyone to cross the finish line,” he told CapeTalk.

RELATED: “A Moral Obligation”: Discovery Employees Must Be Vaccinated From January 1

Dr Whelan says the vaccination was in part influenced by the age groups who became eligible for vaccination in September and October.

He says the company has dealt with an enthusiastic group of employees eager to vaccinate, a more indifferent group who have been “vaccine apathetic” and an anxious group described as “vaccine hesitant.”

We vaccinated 2,200 people in September. To date, we are 9,900 people vaccinated. So we have done 7,200 vaccinations in the last three months. This was the rise in power.

Dr Ron Whelan, COVID-19 Task Force Leader – Discovery South Africa

We still have about 500 people outstanding.

Dr Ron Whelan, COVID-19 Task Force Leader – Discovery South Africa

Different age groups opened up during the months of September and October … It was part of the rise … A lot of people went there voluntarily. In fact, most of our staff were quite anxious to get the shot and get the shot quickly.

Dr Ron Whelan, COVID-19 Task Force Leader – Discovery South Africa

We allowed access to vaccinations, we had mobile sites, we had our Discovery vaccination sites accessible to our staff.

Dr Ron Whelan, COVID-19 Task Force Leader – Discovery South Africa

We had a lot of one-on-one discussions with the staff, just to understand their concerns, to share specific information … and absolutely [brought in their families]… we have recognized that the family is an integral part of this particular point.

Dr Ron Whelan, COVID-19 Task Force Leader – Discovery South Africa


More Business

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Gold price plunges by Rs 2,400 per tola in Pakistan https://piazzacarlogiuliani.org/gold-price-plunges-by-rs-2400-per-tola-in-pakistan/ Sat, 27 Nov 2021 14:28:00 +0000 https://piazzacarlogiuliani.org/gold-price-plunges-by-rs-2400-per-tola-in-pakistan/
– Reuters / File
  • The prices of bullion on the local market are falling by Rs 2,400 per tola and Rs 2,058 per 10 grams.
  • Cumulatively, the precious commodity lost around Rs1,000 during the outgoing week.
  • It drops from $ 26 an ounce to around $ 1,787 in the international market.

KARACHI: Gold lost its luster again as it fell more than 2,000 rupees per tola in Pakistan on Saturday, in line with world markets.

The prices of bullion on the local market fell by Rs 2,400 per tola and Rs 2,058 per 10 grams to reach Rs 122,800 per tola and Rs 105,281 per 10 grams.

Cumulatively, the precious commodity lost around Rs1,000 during the outgoing week.

It fell $ 26 an ounce to around $ 1,787 in the international market, according to All Sindh Saraf Jewelers Association (ASSJA).

Globally, gold was still heading for its worst week since mid-June, down 2.9% so far, under pressure from expectations that the US Federal Reserve could accelerate the rise in prices. interest rate, increasing the opportunity cost of holding non-interest bearing bullion.

Authorities around the world have reacted with concern to the discovery of a new variant of the virus, with the EU and Britain among those tightening border controls as researchers sought to establish whether the mutation was resistant to the vaccine, triggering a massive sell-off in the markets that infiltrated oil and other precious metals. .

But after the rally due to bullion’s appeal as a safe haven, the overall bearish turn in commodities ultimately claimed gold as well, said Jim Wyckoff, senior analyst at Kitco Metals, adding that the market reaction was likely. exaggerated.

Meanwhile, domestic silver prices remained unchanged at Rs 1,460 per tola and Rs 1,251.71 per 10 grams.

– With additional contribution from Reuters

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No TDS obligation for online auctioneers if certain facts are met: CBDT https://piazzacarlogiuliani.org/no-tds-obligation-for-online-auctioneers-if-certain-facts-are-met-cbdt/ Thu, 25 Nov 2021 15:58:15 +0000 https://piazzacarlogiuliani.org/no-tds-obligation-for-online-auctioneers-if-certain-facts-are-met-cbdt/

The Central Commission for Direct Taxes (CBDT) clarified that the withholding tax (TDS) provided for e-commerce operators under Article 194-O of the Income Tax Law will not apply. not to online auction activities conducted by online auctioneers.

This exemption will only be available if the six facts listed by the Central Direct Taxation Council in its latest circular are satisfied. This clarification will not apply if any of these facts are not satisfied.

In addition, it is specified that the buyer and the seller would always be required to deduct / collect the tax in accordance with the provisions of Articles 194Q and 206C (IH) of the Law, as the case may be.

Preconditions

The six facts listed are:

a) The auctioneer performs electronic auction services for his clients on his electronic portal and is only responsible for the price discovery that is reported to the client.

(b) The price so discovered through the electronic auction process is not necessarily the price at which the transaction takes place and it is up to the customer to accept the price or to negotiate directly with the counterparty.

(c) The buy / sell transaction takes place directly between buyer and seller outside of the electronic portal maintained by the online auctioneer and price discovery only serves as a starting point for negotiation and negotiation. conclusion of the purchase / sale.

See also: Plan suggesting tax reduction under vehicle scrapping policy: Nitin Gadkari

(d) The auctioneer is not responsible for facilitating the buying and selling of goods for which the electronic auction has been conducted on its electronic portal, except to the extent of price discovery.

(e) Transactions payments are made directly between buyer and seller outside of the electronic portal and the auctioneer has no information on the quantum and payment schedule which are mutually agreed upon. by the client and the counterparty.

(f) For payment made to the electronic auctioneer for the provision of electronic auction services, the customer deducts tax under the relevant provisions of the Law other than Article 194-0 of the Law.

Stakeholder representations

The Central Council of Direct Taxes had received representations from various stakeholders involved in the activity of providing electronic auction services through electronic portals owned, operated or maintained by them (hereinafter referred to as “electronic auctioneer”).

See also: Regular India-U.S. Trade Policy Forum engagements will help remove trade barriers: USIBC

It has been stated that in an electronic auction, the auctioneer involved in the conduct of the electronic auction through their portal is only responsible for finding out the price for the sale / purchase of goods or services and the outcome of the auction. auction report is submitted to the customer. The customer can be the buyer or the seller. Participants in auctions are sellers (if the customer is a buyer) or buyers (if the customer is a seller). The sale / purchase transaction is carried out directly between the buyer and the seller and not via the electronic portal of the online auctioneer. In addition, the price thus discovered may be further negotiated between the parties without the knowledge of the online auctioneer. In such a scenario, it was represented that the provisions of article 194-0 of the Law do not apply since the sale / purchase transaction itself does not take place via the electronic portal.

Deduction at the time of credit

It may be recalled that the 2020 finance law inserted a new article 194-0 in the 1961 law on income tax, which provides that from 1 October 2020, an e-commerce operator must deduct income tax at the rate of one percent of the gross amount of the sale of goods or the provision of services or both facilities through its digital or electronic facility or platform.

See also: India and US reach compromise on digital tax

However, an exemption from said deduction has been provided for in the case of certain persons or the undivided Hindu family subject to compliance with specified conditions.

This deduction must be made at the time of crediting the amount of that sale or service or both to the account of an e-commerce participant or at the time of payment of the latter to that e-commerce participant, whichever occurs first. contingency.

Government departments

In another related clarification, the Central Council for Direct Taxes said an issue had been raised in cases where a government department would be considered a “seller” for the purposes of tax deduction under the article 194Q of the law.

In this regard, it is specified that for the purposes of article 194Q, the central government or the government of the State will not be considered as “seller” and no tax will be deducted by the buyer, in cases where a department of the central or state government government is a seller of goods, the Central Direct Taxation Council circular said on Thursday.

See also: public comments requested on the cross-border insolvency framework

The Central Direct Taxation Council also clarified that any other person, such as a public sector enterprise or a company established under central or outdated law or any other such body, authority or entity, would be required to comply with the provisions of section 194Q and will be deducted accordingly.

The Central Direct Taxation Council also issued a separate clarification on adjusting various state levies and taxes other than GST.

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While consumers will pay record prices for their Thanksgiving meal, farmers only earn 14.3 cents on every food dollar. https://piazzacarlogiuliani.org/while-consumers-will-pay-record-prices-for-their-thanksgiving-meal-farmers-only-earn-14-3-cents-on-every-food-dollar/ Tue, 23 Nov 2021 16:20:24 +0000 https://piazzacarlogiuliani.org/while-consumers-will-pay-record-prices-for-their-thanksgiving-meal-farmers-only-earn-14-3-cents-on-every-food-dollar/

WASHINGTON – For every dollar Americans spend on Thanksgiving meals this year, farmers and ranchers will earn about 14.3 cents, according to the National Farmers Union.

“Usually Thanksgiving is a time to get together with loved ones and enjoy a great meal,” said NFU President Rob Larew. “But for many Americans, the cost of traditional holiday foods may just be out of reach for some families. “

Even though consumers pay more for food this year, almost none of it is passed on to American family farmers and ranchers. The multiple waves of mergers and acquisitions over the past decades have resulted in uncompetitive, fragile and underpaid agricultural and food supply chains.



Farmers’ share of every dollar that consumers spend on food has fallen from 50 percent in 1952 to less than 15 percent today.

“The National Farmers Union is fighting for tighter enforcement of antitrust laws and to break down corporate monopolies that use their size to unfairly benefit farmers and ranchers while forcing consumers to pay higher prices at the grocery store “, added Larew,



“Enough is enough; someone has to stand up against these corporate monopolies that are destroying family farms and undermining our national food supply.

NFU members actively advocate for the following policy changes to support fair and transparent agricultural markets:

Strengthening the enforcement of the law on slaughterhouses and stockyards

Improve price discovery and ensure fair and accurate market information

Facilitate competition and more diversified market opportunities

Strengthening the enforcement of antitrust laws.

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Loopring has made huge gains in the past 30 days! What’s next for the LRC award? – Coinpedia – Information media on financial technologies and cryptocurrencies https://piazzacarlogiuliani.org/loopring-has-made-huge-gains-in-the-past-30-days-whats-next-for-the-lrc-award-coinpedia-information-media-on-financial-technologies-and-cryptocurrencies/ Sun, 21 Nov 2021 16:11:25 +0000 https://piazzacarlogiuliani.org/loopring-has-made-huge-gains-in-the-past-30-days-whats-next-for-the-lrc-award-coinpedia-information-media-on-financial-technologies-and-cryptocurrencies/

From October 28 to November 10, LRC experienced a staggering increase of over 800%. The LRC entered the price discovery after a bullish pennant breakout on November 7 and hit its ATH of $ 3.85 on November 10.

Since then, the price has been steadily falling, alternating between the descending channel and the ascending channel. As a result, over the past ten days, the token has lost more than a third of its value. Despite an increase of 12.7% on November 19, the trend was accentuated as the movement of prices reversed.

LRC was trading at $ 2.6149 at the time of publication. Although the RSI declined slightly, it remained above the midline, indicating a bullish bias.

Is the long term bias bullish?

LRC’s future course of action remains unclear amid short-term bullish-bearish swings. Therefore, examining the indicators at this stage will provide insight into the future trajectory of LRC.

Considering the DAA price divergence, the chart below shows that the decline has only become stronger in recent days. This is not a good sign, as it highlights the unhealthy nature of the network in addition to the addresses that are active daily.

It is essential that any alternative rally be organic for this indicator to represent bullish streaks on its chart. However, based on the metric’s estimates for LRC, it looks like this alt will struggle to maintain its uptrend phase.

In addition, the average age of coins and the average age of invested dollars have recently seen free declines. One could argue that dormant tokens have started to move as the average age of the money invested in LRC gets younger. And HODLers, especially those who profit from it, have started selling.

If those two curves continue down from here, we’ll see the start of LRC’s complacent race. In practice, we wouldn’t see a lot of coin rallying.

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Hulu + Live TV to increase price to $ 69.99, but now includes Disney bundle (Disney + and ESPN +) – The Streamable https://piazzacarlogiuliani.org/hulu-live-tv-to-increase-price-to-69-99-but-now-includes-disney-bundle-disney-and-espn-the-streamable/ Fri, 19 Nov 2021 17:00:00 +0000 https://piazzacarlogiuliani.org/hulu-live-tv-to-increase-price-to-69-99-but-now-includes-disney-bundle-disney-and-espn-the-streamable/

Hulu + Live TV will increase the price of their live TV streaming service to $ 69.99, but it will now include access to Disney + and ESPN + ($ 15 value). Hulu Live TV customers already had access to the Hulu SVOD plan with the live service.

The $ 5 price hike goes into effect Dec. 21 for new and existing customers. Hulu + Live TV with their ad-free SVOD plan (with Disney + and ESPN +) will be $ 75.99 / month after the price hike (previously $ 70.99).

Those who already pay for Disney + or ESPN + will receive credit for their existing subscription.

Hulu previously offered Hulu + Live TV with The Disney Bundle for $ 72.99 (with ads) and $ 78.99 (without ads), which will save $ 3 per month for those who had these plans.

Their Hulu (with limited ads) and Hulu (ad-free) plans will remain at $ 6.99 and $ 12.99 respectively, after seeing their prices increase by $ 1 in October.

Just last week, Disney announced that Hulu + Live TV has reached 4.0 million subscribers, placing it, along with YouTube TV, as the largest live TV streaming service.

Earlier this year, Hulu added the NFL Network to its base plan and NFL RedZone as part of a new sports add-on. No additional channels should be added with the price increase.

This is the fourth major price increase for the service. In February 2018, the service increased the price from $ 40 to $ 45 after Discovery’s channels were added. In December 2019, they increased the price from $ 45 to $ 55. In December 2020, they increased the price from $ 55 to $ 65.

Hulu Live TV isn’t the only service to increase prices last year.

Sling TV raised the price of Sling Orange and Sling Blue to $ 35 in January, but added a 50-hour DVR to the packages. Philo also increased the price of their service to $ 25 in May, while adding the ability to keep the DVR recording for a year.

Neither YouTube TV, nor fuboTV nor DIRECTV STREAM has increased the price of their service in 2021. However, fuboTV has added regional sports fees in many markets.

YouTube TV last increased the price of its plans from $ 50 to $ 65 (a 30% increase) in June 2020. fuboTV removed its standard $ 60 plan in December 2020, with its new cheapest option from $ 65. AT&T raised the price of its old plan in March, but DIRECTV STREAM has remained at $ 69.99 since last year.

With the annual increases in content costs – and the continuing fattening of live TV streaming service bundles, it’s no surprise to see annual price increases for the services. The question is, how far will they go before customers completely forgo over-the-air TV.

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100 years after the discovery of insulin, the disparities persist https://piazzacarlogiuliani.org/100-years-after-the-discovery-of-insulin-the-disparities-persist/ Wed, 17 Nov 2021 17:21:23 +0000 https://piazzacarlogiuliani.org/100-years-after-the-discovery-of-insulin-the-disparities-persist/

This November marks the centenary of the discovery of insulin, an event that transformed diabetes care “from a death sentence to a chronic disease,” says the Endocrine Society. And while progress has been made in access and distribution over the past century, a new review published in The Lancet details the current challenges facing children and adolescents with type 1 diabetes (T1D) in low- and middle-income countries (LMICs).

“Most types of insulin are still administered by subcutaneous injection and do not completely mimic the time profile of physiological insulin secretion over time,” the authors explained. But despite “improvements in new formulations of insulin and clinical development of biosimilar insulin in recent years, metabolic outcomes in diabetes have not changed dramatically,” they said.

Reports estimated that a total of 463 million people worldwide suffered from T1D in 2019, and one study found that the incidence of T1D in children and adolescents increased by an average of 2.8% between 1990 and 1999.

However, due to the paucity of representative population-based data, estimates likely underestimate the true cost and burden of T1D, a problem compounded by potential premature deaths before diagnosis. For example, in Africa few countries report data on relevant indicators, meaning that estimates may be based on an extrapolation from neighboring countries, the researchers said, leading to potential inaccuracies.

In addition, different regions report variability in the management of pediatric T1D. Data show the proportion of children with optimal glycemic control (glycated hemoglobin [A1C] <7.5%) is 32.4% in high income countries (LICs) compared to only 12.7% in low income countries (LICs).

Global Health Observatory estimates indicate that less than half of countries in Central Asia, East Asia and West Sub-Saharan Africa have existing diabetes registries, availability of insulin, the existence of operational policies and facilities for diabetes screening in primary health care. level. “Only 20% of Central and South Asian countries have generally available insulin,” noted the authors.

A combination of these factors, in addition to inadequate infrastructure, diagnostic tools and personnel, lead to reduced and delayed T1D diagnoses in LMICs.

Since T1D involves the destruction of β cells, which can begin months or years before diagnosis, the process is often non-linear. Although several landmark studies have been published on risk factors for T1D, ethnic minorities and LMIC populations are often under-represented.

More inclusive analyzes are needed “to explore risk factors in various settings with varying risks, including those related to inbreeding,” the researchers noted.

In the treatment and management of T1D, the focus has shifted from symptomatic treatment to disease-modifying interventions. One development in this area is the development of teplizumab for people who are antibody positive and at high risk for T1D.

“Stage 3 prevention trials aim to preserve some of the β cell function to potentially delay complications of T1D and enroll children within 100 days of diagnosis of T1D,” said the authors. But the need to undertake similar studies among existing cohorts in LMICs remains crucial.

In a review of the literature published after 2015 on pediatric management of T1D, researchers found that the majority of evidence focused on interventions on health outcomes and quality of life came from studies in HICs; the data available from PRFIs were too scarce to draw meaningful conclusions.

While technological advances in insulin delivery, mainly implemented in HIC, have revolutionized the lives of people with T1D, these advances “do not take away from the reality of the differences and inequalities in access. to care, even in HICs like the United States, where price scams and the availability of insulin have negatively affected the care of children and youth with diabetes, ”the researchers wrote.

In recent years, the use of continuous glucose monitoring (CGM) in children and adolescents has grown, as parents can remotely monitor glucose levels and help reduce the risk of hospitalization due to diabetic ketoacidosis. Such promising results require the implementation of these interventions in children with LICs.

Over the past century, the life expectancy of pediatric patients with T1D has increased, although gains have been much slower in LMICs. Despite the lack of longitudinal studies on the long-term prognosis of T1D in LMICs, an analysis conducted in South Africa found that over 20 years, mortality in patients with T1D was 43%, renal failure , with hypoglycemia and ketoacidosis being the main causes of death. . Overall, “T1D patients in LMICs have high mortality rates and a high disease burden”, with poor administration of treatment largely due to the availability and cost of insulin.

According to the authors, an important step in overcoming these obstacles is the implementation of universal health coverage (UHC).

“Regardless of the path countries take to achieve UHC, there are few interventions more essential and life-saving than those for the management of T1D in children and adolescents, and it is crucial that these interventions, especially those for treatment, are available to people who are poor and are publicly funded, ”they said.

“For these goals to be achieved, countries must aim to achieve an 80% level of availability of essential drugs and technologies, as proposed in the WHO Global Plan of Action on Noncommunicable Diseases. “

It is estimated that among countries without public health system coverage for T1D, basic health care supplies for the disease have a median cost of 56% of the average annual income of individuals, or 153% in the highest income group. weak. Training physicians in LMICs in managing T1D and investing in community health workers could help alleviate some of the barriers to care.

To mitigate insulin costs, duties and taxes could be eliminated while price regulation and transparency could improve accessibility in the context of LMICs, the authors said.

“As the world rebuilds itself from the ravages of COVID-19, it is imperative that the needs of children and adolescents with T1D receive full attention,” they concluded.

Reference

Bhutta ZA, Salam RA, Gomber A, et al. A century after the discovery of insulin: Global progress and challenges for type 1 diabetes in children and adolescents in low- and middle-income countries. The Lancet. Published online November 13, 2021. doi: 10.1016 / S0140-6736 (21) 02247-9

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The Case for a Long Position in the Price of Gold in November https://piazzacarlogiuliani.org/the-case-for-a-long-position-in-the-price-of-gold-in-november/ Mon, 15 Nov 2021 16:13:48 +0000 https://piazzacarlogiuliani.org/the-case-for-a-long-position-in-the-price-of-gold-in-november/

Now is the time to go long in gold? We think so. There have been several false dawns for the price of gold, with the usual gold bugs trying to egg on the market and a number of interesting conspiracy theories circulating in the market. Many investors would like to know why gold is constantly in a holding pattern when other assets like Bitcoin appear to be reacting to the higher inflation numbers we are seeing.

Today we are in a long gold trade with the expectation that central banks do not have inflation under control and that investors will now start buying gold and gold mining stocks.

Inflation numbers are now starting to look a bit more worrisome, and there will be plenty of investors buying gold as they see these readings. Bitcoin won’t be a cave big enough for everyone to hide.

Are central banks starting to lose track?

“The release of record US CPI inflation data for October has seriously undermined the Federal Reserve’s long-held argument that high inflation will prove to be ‘transient,’ said Olivier Desbarres, founder of 4X Global Research. “What turned out to be transitory was the rise in yields on short-term government bonds in developed markets, in line with our expectations. Adverse base effects no longer explain the high year-over-year inflation, with US inflation now well above the pre-pandemic trend. “

Desbarres says the Fed has little control over international energy and commodity prices and, coincidentally, seems intent on letting consumer demand (and the economy) heat up for a while.

Let’s look at the technical indicators

There are also technical indicators that seem to show that gold is preparing for something more. On November 5, gold hit a shorter-term intermediate high at $ 1,813 for the first time in a long time. If (when) 1834.15 is withdrawn, then the series of falling highs and downtrend line from the all-time high of 2075 cash (future 2089) in August will also be broken.

Long-term golden image

The double bottom between 1670 and 1675 could change the structural status of the market to become a double bottom and a base for the next bullish round, potentially into a new ATM.

Signals to buy gold have appeared in other currencies and on October 31, gold posted the highest monthly close against the JPY, indicating this strong bullish sentiment, earlier than against the USD. Against the Euro, the breakout of the downtrend line occurred on October 12, and the structural breakout also occurred on November 5.

Short term golden picture

“Combined with the current impressions of inflation in the background, giving the impression that central banks are losing the war on inflation and that the ‘transitional’ situation was only transitory when it came down. This is about the broader confidence in the ability of central banks to control yields, AND if central banks win and continue to be successful in their fight against yields, this will provide strong negative real returns and the best possible fundamental backdrop for the upside. of gold prices historically, ”said Henrik mikkelsen, Vice President at Cloudbreak Discovery and CIO at Iridis in Zug, Switzerland.

Mikkelsen says that for the gold bugs, things seem to be improving. He believes that technically the bullish picture for gold will remain positive as long as the 1834 break point is kept intact on closing prices. If he goes below that, he believes, things will turn badly again.

“A test and rejection of the 1834 level – giving it a margin of $ 5 – would be optimal for a strong outlook for gold and good positioning for gold and gold stocks,” he said. “Both assets need to stay positive, otherwise the credibility of the signals will cloud, and maybe something else is at stake.”

Our gold trade

So on the gold trade. For a short term tactical trade like this, we add the trade to our portfolio of trading ideas which manages a trailing 10% stop loss. We would only use contracts for difference or spread bets on a much shorter term calculation and believe overnight funding rates would be crippling for this one. An Exchange Traded Fund would be a cheaper way to access this trade.

Here are six gold ETFs that are proving popular in the market:

  • WisdomTree Physical Gold USD
  • SPDR USD Gold Shares
  • iShares Gold Trust USD
  • ETF ZKB Gold AA CHF
  • ETF Aberdeen Standard Physical Swiss Gold Shares
  • Swisscanto Precious Metals – Physical gold

We opt for the SPDR Gold Shares ETF (NYSE: GLD) ourselves, as it tracks the LBMA London Gold Market Fixing Price PM index. It offers physical exposure and is listed on several exchanges in various currencies including USD, EUR and HKD (Hong Kong Exchanges & Clearing). It has over $ 58 billion in assets, a tracking error of 0.38%, and a total expense ratio of 0.40%.

It is possible to find more leveraged versions of gold ETFs in the market, at x2 or x3 levels. ETFs have the advantage of being able to trade like normal stocks and some – not all – may qualify for an ISA.

Trade Details

  • Long Gold
  • Instrument type: ETF
  • Instrument: SPDR Gold Shares USD (NYSE: GLD)
  • Entrance fee: $ 173
  • Target: $ 250
  • Stop loss: 10%
  • Portfolio: Tactical trading

Related

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Grassley praises compromise proposal in cattle market – KIWARadio.com https://piazzacarlogiuliani.org/grassley-praises-compromise-proposal-in-cattle-market-kiwaradio-com/ https://piazzacarlogiuliani.org/grassley-praises-compromise-proposal-in-cattle-market-kiwaradio-com/#respond Wed, 10 Nov 2021 15:43:26 +0000 https://piazzacarlogiuliani.org/grassley-praises-compromise-proposal-in-cattle-market-kiwaradio-com/

IARN – Iowa Senator Chuck Grassley praises a bipartisan compromise bill that seeks to restore fairness to the livestock market dominated by four large meat slaughterhouses.

On Tuesday, Grassley joined Senators Deb Fischer of Nebraska, Jon Tester of Montana and Ron Wyden of Oregon in announcing the Cattle Price Discovery and Transparency Act. Grassley told farm reporters the bill was a compromise between his 50/14 legislation and Senator Fischer’s Livestock Market Transparency Act.

“You’ve heard me tell you so many times about my top priority to pass legislation to improve market conditions for independent cattle producers,” Grassley said. “I am proud to report that we are one step closer to making this happen.”

Grassley says Iowa cattle producers need legislation that will help alleviate the gaps and concerns in the cattle market that have long plagued the industry.

“I have heard directly from livestock producers who think they are not getting a fair price for their cattle from the Big Four Meat Slaughterhouses while they are raking in the profits,” Grassley said. “You heard me say some numbers from June, where one week packers were making $ 1,200 per head, then another week, $ 800 per head. The farmers were doing nothing.

Grassley explains some of the key measures of the compromise legislation.

“Our bill contains strong provisions that were included in my Bill 50/14, including new reports for packers,” Grassley said. “Although I had to compromise on the mandatory 50% minimum of spot traded transactions, I believe the bill will stop the erosion of the spot market. “

Grassley said senators plan to introduce the Livestock Price Discovery and Transparency Act in the coming days.

“Next month will be critical as we discuss with the leaders of the House and Senate agriculture committees to have the bill included in the re-authorization of mandatory livestock reporting legislation,” he said. Grassley said. “Producers across the country are counting on Congress to make real reforms to the livestock market, and that’s one of my two big goals for this year. “

The proposal is endorsed by a number of state and national organizations, including the Iowa Cattlemen’s Association, the Iowa Farm Bureau, the American Farm Bureau, the National Farmers Union, and the US Cattlemen’s Association.

Story courtesy of the Iowa Agribusiness Radio Network.

Photo courtesy of Senator Grassley’s office

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